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Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells

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However, the authors mentioned that the presence of visible product-related particles during stability storage in any drug product requires a thorough product-specific safety assessment that, at minimum factors in the mechanism of action of the drug, the route of administration, patient population as well as the visible particle size/count

The two most notorious culprits are Proton Pump Inhibitors (PPIs) , used for acid reflux, and Metformin , the first-line treatment for Type 2 diabetes