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Arch Biochem Biophys 281, 4143

Follow-up studies combining mitochondrial metabolite profiling, organelle transport assay and structure-guided mutagenesis identified a critical role of SLC25A39 in mitochondrial glutathione uptake, a discovery that has also been independently reached by a recent report 14

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Furthermore, MPTP decreased mitochondrial biogenesis signaling (SIRT-1, PGC-1 and TFAM), as well as mitochondrial marker VDAC expression, while HBOT treatment was shown to upregulate protein expression

doi: 10.3945/ajcn.2009.28095 63 CaniPDPossemiersSVan de WieleTGuiotYEverardARottierOet al