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This review highlights the prevalence, molecular mechanisms and combating approaches of underlying risk conditions by managing endothelial dysfunction, hypertension, and platelet hyperactivity/prothrombotic state with bioactive compounds like polyphenols, small molecules like miRNA, and gene therapy

Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimers disease (5FAD) mice, reduced A and IL-6 levels, inhibited A plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice (Belaya et al., 2021)

La Rocca, C., Carbone, F., Longobardi, S

The underlying chronic inflammatory state is therefore expected to exacerbate pain through mechanisms similar to those described in other inflammatory disorders

The chondral defect (4 mm in diameter) was created in the trochlear groove of the distal femur according to a previously described method [24]