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doi: 10.1006/bbrc.2000.3197
Plant defence against herbivory and insect adaptations
GSCs, like normal stem cells, maintain low ROS levels, which is in contrast to the high ROS levels in cancer cells (Mittal et al., 2014)
Based on these results, we propose that inhibition of RNR (or upstream enzymes) leads to accumulation of GSH which can be re-purposed for use by GPX4 to prolong the inhibition of ferroptosis under conditions where new GSH synthesis is otherwise impossible (Fig 6)
[DOI] [PubMed] [Google Scholar] Marazzi MC, Mancinelli S, Paolmbi L, Martinoli L, DAlessandro de Luca E, Buonomo E, et al
