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Non-selective MAO-I due to their side-effect/adverse reaction profile, like tranylcypromine have limited use in the treatment of depression in PD, while selective, reversible MAO-A inhibitors are recommended due to their easier clinical handling

safety outcome) in adults with AD

Therefore, it should be administered multiple times to prevent plasma level fluctuations [12, 13]

Therefore, deficient OCM pathways lead to considerable neuronal damage and toxicity (Table 1)

doi: 10.1038/s41591-018-0290-5 49 VelascoCRBrandlSMMelendezAVSchlaakAEBuschkyAPetersTet al
