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Description
Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors
Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinsons disease
Then, GSH swoops in to restore the enzyme, getting oxidized in the process
doi: 10.2147/IJN.S79879 75 GurunathanS.HanJ.ParkJ
doi: 10.1016/S0959-8049(02)00229-0
