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Six-to-12 months later, the patients were asked to recall if their pain had improved

First: the lipolytic effect in animal models (in rats and mice on a high-fat diet) did not translate to humans with stabilized obesity

Researchers raise doses in animals until roughly 50% die, giving a crude measure of acute lethality that does not translate directly to human safety but gives context for risk margins

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1 2 "Living With Pernicious Anemia"