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Histamine Overload and MCAS Flares: As a key component of Phase II liver detoxification, glutathione accelerates the clearance of circulating histamine and inflammatory cytokines, helping to reduce flushing, itching, and sudden allergic-like reactions

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Physical exercise stimulates the release of endorphins and promotes neurogenesis, whereas vitamin D influences serotonergic neurotransmission and provides neurotrophic support, thereby contributing to enhanced mood and cognitive resilience ( Figure 3 )

Immunol Rev 270:95112 Moreno L, Perez C, Zabaleta A, Manrique I, Alignani D, Ajona D et al (2019) The mechanism of action of the anti-CD38 monoclonal antibody isatuximab in multiple myeloma

Prostaglandins have been used topically to stimulate melanogenesis, while Melitane, a biomimetic peptide that activates the melanocortin one receptor, has shown promise in promoting hair pigmentation