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The fasted state is criticalinsulin suppresses NNMT activity, so dosing during fed states reduces 5-Amino-1MQ's efficacy

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Since diagnosis, she has been treated with OHCbl, folic acid (7.5 mg per day), and betaine (up to 6 g per day)

doi: 10.1038/414782a

This is especially important for those who may have difficulty absorbing nutrients due to digestive issues, certain medical conditions, or simply because of age-related changes
