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Such conflicting results reported in low-quality studies are also biased because of various limitations in study designs, like a retrospective casecontrol design, prior undiagnosed medical conditions, medical history and time until the occurrence of the studied event, CRP measurement with various assays of different specificity/sensitivity/LoD scores/etc., different medication strategies, history of medications, relatively small study sample sizes, etc

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(1999): Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression