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PMID: 23286972

(6) Inadequate levels of B12 can disrupt this cycle and lead to the accumulation of homocysteine, which is toxic to neurons and poses an increased risk factor for cardiovascular disease, stroke, and cognitive decline

Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation were considered to be similar mechanisms for chronic SF and neurodegenerative diseases [67]

Vora DK, Fang ZT, Liva SM, Tyner TR, Parhami F, Watson AD, Drake TA, Territo MC, Berliner JA

After reconstitution, visible particulates, cloudiness, or an unusual increase in solution viscosity indicate aggregation and loss of monomeric peptide content