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Diaz-CanestroCPuspitasariYMLiberaleLGuzikTJFlammerAJBonettiNRet alMMP-2 knockdown blunts age-dependent carotid stiffness by decreasing elastin degradation and augmenting eNOS activation

Specifically, HIF-1 in human coronary artery endothelial cells has been shown to induce EndoMT and promote cardiac fibrosis through snail activation (169)

In the context of low BH 4 concentrations, nitric oxide synthase produces peroxynitrite, an unstable reactive nitrogen species that can result in oxidative cellular damage

10.1016/j.bbrc.2020.08.091 Biochem Biophys Res Commun

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