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doi: 10.1097/00003072-199901000-00007
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Unlike other TGF- superfamily proteins, the mature C-terminal domains of GDF8 and GDF11 remain tightly bound to their prodomains even after Furin cleavage and require TLD cleavage of the prodomain to convert from an inactive to a triggered state that is primed for subsequent activity of the mature, signaling-competent ligand [73-75]
