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Description
Androgen deprivation therapy (ADT), the first line of treatment for progressive prostate cancer, is effective at first but eventually fails due to the development of resistance, primarily through androgen-independent reactivation of AR [2]
Those fluctuations stress peptide bonds and accelerate degradation
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Suppression of glutaminolysis by inhibiting GLS (CB839
doi: 10.1042/BJ20031049
