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Disagreement about the selection of studies was resolved by discussion and consensus

Neural Tube Protection The neural tube is an anatomical structure that arises during the early stages of embryogenesis in humans, ultimately giving rise to the central nervous system, including the brain and spinal cord

Baseline labs and targeted follow-up for liver and kidney function, glucose, lipids, and relevant hormones help catch problems early

For acute OIPN, the dysfunction of ion channels, OCT protein, and glial cells are involved in the acute pain, whereas the main mechanisms relevant to chronic OIPN are nuclear DNA damage, oxidative stress-induced mitochondrial damage, glia activation-related neuroinflammation, and gut microbiota-induced inflammation (Fig