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published the lenalidomide-based PROTAC 93 for ibrutinib-resistant malignant lymphoma in 2023

Schuepbach, W

60,61 A third redox-sensitive pathway groupincluding Wnt/-catenin, PI3K/AKT/mTOR, aryl hydrocarbon receptor (AhR), TGF-, calcium signaling, Janus kinase (JAK)/signal transducers and activators of transcription (STAT), hypoxia-inducible factor 1 (HIF1), NF-B, Nrf2, c-Jun N-terminal kinase (JNK), p38, and Ataxia-telangiectasia mutated (ATM)features components that shuttle between the cytoplasm and nucleus, allowing complex regulation of gene expression and cellular fate

Characterising increased bone mineral density, enhanced osteocalcin production, and improved skeletal parameters , without the cortisol co-elevation-associated catabolic bone effects that confound non-selective GH secretagogue bone biology studies

10.1038/s44276-024-00043-z 129
