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Korean Journal of Pediatrics, 58 (2), 41-46

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Translocation can occur due to active virulence mechanisms that allow bacteria to cross the barrier or may be passive when barrier failure has already occurred

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Answering the Question Be cautious

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Hydroxocobalamin 1mg is the standard UK formulation, typically administered every two to three months for maintenance therapy Self-administration requires GP prescription, competency training from practice nurses, and demonstration of proper injection technique Common injection sites include the thigh (vastus lateralis) for both intramuscular and subcutaneous administration with site rotation essential Serious side effects are rare but anaphylaxis requires immediate 999 call

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Acknowledgements This work was supported in part by the Rehabilitation Research & Development Service of the US Department of Veterans Affairs Office of Research and Development and The Cleveland Clinic

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