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Iron-deficient RBCs show features of apoptosis (shrinkage, membrane blebbing, phosphatidylserine exposure) and are removed by splenic macrophages

Targeting One-Carbon Metabolism for the Treatment of Disease While the above research suggests that supplementation with FA and B12 could potentially be harmful, B12 supplementation, even in patients with normal serum B12 levels, has been explored to counteract certain neurological defects, given that B12 deficiency can cause neurological symptoms