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Over 96 weeks, 178 (44%) of 402 patients in the cladribine 3.5 mg/kg group and 189 (46%) of 411 patients in the cladribine 5.25 mg/kg group were free from disease activity versus 60 (16%) of 379 patients in the placebo group

The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

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