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When there is thiamine deficiency, the thiamine dependent enzyme alphaketoglutarate dehydrogenase (KGDH) will not be activated and will result in damage of the mitochondria and eventually cause cell death 4

doi: 10.1016/S0140-6736(18)30485-9 190 BharathLPAgrawalMMcCambridgeGNicholasDAHasturkHLiuJet al

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And if you can maintain that, I would imagine that it would have some interesting effects