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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, et al

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Glycolysis inhibition In the dysregulated substrate flux and redox imbalance during ischemic stroke (metabolic chaos), the brains compensatory shift toward anaerobic glycolysis (a Warburg-like adaptation) initiates a pathogenic cascade: lactate accumulation drives cytotoxic acidosis while concurrently fueling enzymatic lipid peroxidation, demanding targeted strategies to modulate this maladaptive energetic response [133, 207]