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In 1951, Giulio Cantoni purified NNMT partially and characterized its methyltransferase activity for the first time [3]

Its primary job is to take nicotinamide (a form of vitamin B3) and methylate it, effectively taking it out of circulation for a critical cellular process: the NAD+ salvage pathway

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Comparison with oral options and other injectables Some people prefer oral supplements because they avoid needles entirely

Patient Education / Summary The following summary is intended for use in patient-facing materials, care coordination notes, and health literacy communications consistent with ADA 2026 Standards of Care, Section 5 (Facilitating Positive Health Behaviors)