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Storage temperature consistency Optimal: 2-8C (36-46F) constant Temperature fluctuations shorten shelf life: Frequent door opening warms vials temporarily Power outages or fridge malfunctions Storing in fridge door (warmest, most variable location) Best practice: Store in main fridge section (not door) Middle or back of shelf (most stable temperature) Away from freezer section (avoid freezing) Avoid frequent removal for extended periods Light exposure Peptides degrade faster with light exposure, especially UV light

Only amino acids with small or similar side chains to serine at position 586 retained decarboxylase activity, suggesting that reduced steric hindrance is advantageous

doi:10.1007/s13258-021-01199-5

[PubMed] [Google Scholar] 5.Monafo W.W., West M.A

More importantly, although we have collated the evidence on the penetration of hepatokines into the BBB, variations in research approaches and indirect measurements introduce uncertainties