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Abnormalities in chromosome structure and number have been found in 4% of patients with azoospermia or oligozoospermia, as an abnormal chromosome structure leads to abnormal meiosis and spermatogenesis failure ( Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila (fruit fly), and Mus musculus (mouse) ( Sperm dysfunction is the most common cause of infertility in men

doi:10.1016/s0142-9612(03)00348-x

Cancer metabolism: the Warburg effect today

However, the study is limited by its 12-month follow-up period, thereby restricting the observation of potential long-term side effects associated with oral estrogen therapy beyond this timeframe

Abbott, K