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Within the mitochondria, leaking electrons resulting in ROS production occurs predominantly at complexes I and III of the ETS in a resting state, though superoxide may also be produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase ( Figure 1 While the antioxidant capabilities of Se have been a popular and integral subject of investigation, there are a vast array of additional biological roles of Se, some which may be extensions of antioxidant activity but others which are unrelated to Se's redox role that may be overlooked

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Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, Roigaard H, Gliemann J, et al