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for: Vitruvias Therapeutics Auburn, AL 36830 PRINCIPAL DISPLAY PANEL Cyanocobalamin Injection, USP 30,000 mcg/30 mL (1,000 mcg/mL) NDC 6968012105 5 x 30 mL MULTIPLE DOSE VIALS For Intramuscular or Subcutaneous Use Only Each mL contains: Cyanocobalamin 1000 mcg, Benzyl Alcohol 1.5%, Sodium Chloride 0.9%, Water for Injection q.s

Selective NNMT inhibitor substrate site-targeting mechanism with IC50 of 1.2 M in reference assay conditions Selectivity over related methyltransferases does not significantly affect other enzymes in the NAD salvage pathway at research concentrations Reduces intracellular 1-methylnicotinamide (1-MNA) formation in cell-based assay models Studied in adipocyte, liver, and skeletal muscle cell-based research models examining NNMT-dependent methylation pathway dynamics Referenced at Sigma-Aldrich (SML2832) and in peer-reviewed literature on NNMT enzyme biology Membrane-permeable quaternary quinolinium scaffold studied for intracellular NNMT target engagement in cell-based models Batch and lot identifiers on all labeling for full laboratory documentation compliance Research Background 5-Amino-1MQ was first characterized as a selective NNMT inhibitor in published research literature in 2018

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For patients dealing with specific injuries, joint pain, or post-surgical recovery, BPC-157 is typically the primary choice

J., Chen, H