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In an open uncontrolled trial, 32 IC/BPS patients were treated with 400 mg micronized PEA plus 40 mg polydatin (a naturally occurring precursor to the polyphenol resveratrol) twice daily for three months followed by once daily for three months

But because human data support the interaction, caution and monitoring are appropriate

(1996) Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats