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Synergistic and competitive interactions governing the redox plasticity of Pt nanozymes While the preceding sections delineate the discrete catalytic mechanisms of individual enzyme-like activities, the therapeutic efficacy of Pt nanozymes hinges on the dynamic interplay, competition, and synergy among these multimimetic functions within complex pathophysiological microenvironments

Cell Death Discov 10:116

We propose that stabilization of wild-type p53 and induction of p21 can link down-regulation of RNR-associated gene expression to protect against ferroptosis

However, a single transplantation is insufficient, as patients present a plateau growth velocity at some point

Building on this foundational role, PPRs antioxidant effects further contribute to its therapeutic profile