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In PTEN-deficient breast cancer, the expression of PI3K in tumor cells significantly hampers the infiltration of CD4+ and CD8+ T cells via the BMX/STAT3 signaling pathway, leading to the formation of an immune desert within tumors and facilitating tumor immune evasiveness

Luc JGY, Archer MA, Arora RC, Bender EM, Blitz A, Cooke DT, Elde S, Guy TS, Halpern AL, Harrington C, Hlci TN, Kidane B, Olive JK, Ouzounian M, Stamp N, Vervoort D, Varghese TK, Antonoff MB

Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)