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Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle1- AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF- dependent cell scattering

Public docket FDA-2025-N-6895: Open for written comments through July 22, 2026, the day before the meeting convenes

Frequency: Once per day (subcutaneous), preferably in the evening

Horm Metab Res 33 : 156162 Scavo LM et al