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Unlike L-arginine, oral ingestion of L-citrulline is not catabolized by arginase in the intestine, and the enzymatic activity of argininosuccinate synthetase (the enzyme that catabolizes L-citrulline) is relatively low in intestinal epithelial cells [45]

[51] Infiltration is one of the most common adverse effects of IV therapy [52] and is usually not serious unless the infiltrated fluid is a medication damaging to the surrounding tissue, most commonly a vesicant or chemotherapeutic agent

Korean J Physiol Pharmacol 17(5):427433

2.2 PICOS framework To ensure a systematic approach to our review, we employed the PICOS framework as illustrated in Figure 2

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