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Oral supplements require intrinsic factor for absorption, and many people (especially those over 50) have reduced absorption capacity

Participants with higher vitamin B12 levels were more likely to have a BMI in the normal or underweight range

In addition, if your deficiency is caused by intestinal problems (such as celiac disease or Crohns disease), the effectiveness of oral supplements may be greatly reduced because the bodys ability to absorb vitamins through the intestines has been impaired

If you are struggling to achieve HbA1c targets despite metformin and lifestyle modifications, tirzepatide offers substantial improvement potential

It is commonly used in individuals with pernicious anemia, gastrointestinal disorders that affect absorption, and in those who follow a strict vegan or vegetarian diet