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The persistent hyperglycemia in diabetic patients leads to the massive deposition of AGEs in endothelial cells, glomerular basement membrane and podocytes, directly damaging the normal structure of the glomerulus, impairing filtration function, and leading to the production of proteinuria (Wu et al., 2021)

doi: 10.1016/j.cmet.2021.11.010 193

In contrast, higher temperatures favor the slower, product-inhibited cycle, potentially resulting in superoxide accumulation

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178 Further investigations found that during follicular phase, UPA causes a significant increase in the expression of a protein involved in chondrocyte differentiation (called Indian Hedgehog) and in genes involved in its signaling