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All CMNs, like any pigmented lesion, should be assessed for clinical characteristics of melanoma using the classic ABCDE checklist (Box 7-4)

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Reliable Employs anti-CD3/CD28 antibodies and a proprietary additive to modulate the CD4+:CD8+ ratio in a dose-dependent manner

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Immunohistochemistry (IHC) also revealed that the tumor was positive for multiple additional melanocytic lineage markers, including SOX10, S100 protein, MITF, and HMB-45 (Figure 3D) but negative for CK8/18 and synaptophysin

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