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Data Animal Data Reproduction studies have been performed following administration of acetylcysteine during the period of organogenesis in rats at oral doses up to 2000 mg/kg/day (1.1 times the recommended total human intravenous dose of 300 mg/kg based on body surface area comparison) and in rabbits at oral doses up to 1000 mg/kg/day (1.1 times the recommended total human intravenous dose of 300 mg/kg based on body surface area comparison)

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Jain H., Prabhakar B., and Shende P., Modulation of Olfactory Area for Effective Transportation of Actives in CNS Disorders, Journal of Drug Delivery Science and Technology 68 (2022): 103091