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Melanotan II (MT-II) is a synthetic cyclic heptapeptide and a "super-agonist" of the melanocortin receptor system
Cholesterol synthesis takes place in the cytosol, and the acetyl-CoA needed can be obtained from several sources such as -oxidation of fatty acids, the oxidation of ketogenic amino acids, such as leucine and lysine, and the pyruvate dehydrogenase reaction (acetyl-CoA shuttled out of the mitochondria is in the form of citrate, which is cleaved into acetyl-CoA and pyruvate by citrate lyase)
TAM A family of proto-oncogene tyrosine kinase receptors (Tyro3, Axl and MerTK)
AlphaFold2-assisted structural prediction reveals an elongated hydrophobic tunnel in LPD-3 suited for lipid trafficking
