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Drug-target residence time: critical information for lead optimization

In each case the data generated must be viewed within the context of the limitations imposed by the procedures employed to extract and estimate GSH:GSSG ratios in vitro or to probe glutathione pools in situ

Recently, nicotinamide N-methyltransferase (NNMT) has been emerging as a new mechanism-of-action target in treating obesity and associated T2D

Uchida Y, Yagi Y, Takao M, Tano M, Umetsu M, Hirano S, et al

Surg Endosc (2006) 20:16714.10.1007/s00464-005-0660-1 35 ForbesJFryNHwangHKarimuddinAA
