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Adequate hydration, moderate fat intake (very low-fat diets paradoxically increase gallstone risk by reducing gallbladder contractility), and ursodiol prophylaxis for patients with known gallbladder disease risk factors may reduce this concern

Adequate vitamin D levels are important for maintaining normal immune system function, musculoskeletal health, and overall physiologic balance

In cancer-associated fibroblasts, NNMT drives angiogenesis through the ETS2VEGFA axis via epigenetic reprogramming

Choline depletion results in decreased fat metabolism and utilization

Conclusion While vitamin B12 injections are effective and generally safe, rare but serious adverse effects such as hypersensitivity and anaphylactic reactions can occur, particularly with parenteral administration