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Mechanistically, it could be because PI3K activates AKT via downstream molecules, and AKT activates mTOR by phosphorylation

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[DOI] [PubMed] [Google Scholar] 399.Bischoff-Ferrari H.A

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In newborns, bilirubin can cross the blood brain barrier and cause neurological issues such as kernicterus or acute bilirubin encephalopathy [29]

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