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Mainly through these mechanisms (27), Pycnogenol supplementation has been shown in RDP human clinical trials to beneficially affect cardiovascular health (9, 11, 12, 2022, 2831), chronic venous insufficiency (32, 33), cognition (13, 14, 3439), joint health (4042), skin health (43, 44), eye health (45, 46), womens health (12, 47, 48), respiratory health and allergies (4951), oral health (52) and sports performance (5356) (Figure 2)

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A single endocannabinoid-like lipid, 2-oleoyl-glycerol (2-OG), was associated with significantly different levels between groups

Metabolic rate increases occur through multiple mechanisms including brown adipose tissue activation

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