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Similarly, paclitaxel binds with -tubulin, the main component of the mitochondrial membrane, and opens the mitochondrial permeability transition pore (mPTP), resulting in a rapid mitochondrial depolarization and cytochrome c release from mitochondria in a neuroblastoma cell line ( in vitro studies, paclitaxel-induced mitochondrial dysfunction significantly hampered cellular respiratory function and ATP production in DRG neurons (Ikegami and Koike, 2003

Administration and Timing DSIP is most commonly administered via subcutaneous injection, though some literature reports intravenous administration in controlled clinical trials

The most commonly used form for supplementation, both injectable and oral, is cyano-B12, which contains a cyanide moiety attached to cobalamin