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43,44,45,46 Other notable conditions frequently excluded were a history of cancer within 5 years (52%), immunocompromised state (45%), and vascular disease of the lower extremity (42%)

Both can be highly effective when paired with diet and exercise changes

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Instead, strategies that simultaneously address the multiple root causes of NAD+ decline such as the combined administration of a NAD+ precursor, a CD38 inhibitor, and an NAMPT activator, hold potential for NAD+ restoration with greater measurable benefits (Fig