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Therefore, studies have investigated how CHAC1 is regulated in tumor cells and their microenvironment: Prostate cancer patients frequently develop resistance to docetaxel, a challenge in which cancer-associated fibroblasts (CAFs) have been shown to play a significant role through exosome-mediated signaling (Giraldo et al., 2019
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It protects hexokinase 2(HK2) from high glucose (HG) stimulation
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