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The basic strategy associated with the creation of inducible knockout mice is elegantly simple and capitalizes on the absence of these recombination pathways in mammals

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NOS2 expression is suppressed by p53, whereas high NO levels promote p53 stabilization due to its phosphorylation at Ser/Thr residues as well as intracellular p53 accumulation followed by the cell cycle arrest and apoptosis initiation [56, 57]

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