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The RNAs from the WT, R1.40 and APP/PS1 cortex with or without cuprizone treatment were subjected to analysis using a panel of the 416 genes covering nine major pathways associated with age-related pathology, including angiogenesis (12.2%), apoptosis (8.5%), cell cycle (18.3%), cell senescence (6.3%), DNA damage & repair (14.8%), epithelial-to-mesenchymal transition (11.1%), hypoxia (12.2%), metabolism (11.1%) and telomeres/telomerase (5.7%, see gene list in Table S1)

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Another study showed that TLR-4 is required for lactoferrin to activate the anti-viral state in host cells against vesicular stomatitis virus, but TLR-4 is dispensable in lactoferrin stimulation of TNF- production [96]

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We further characterized rS1p pro-inflammatory responses in hMECs by measuring expression profiles and production of pro-inflammatory mediators