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Key points about elevated B12: Water-soluble vitamin with significant hepatic storage capacity Elevated levels defined as exceeding laboratory upper reference limit Often discovered incidentally during routine blood tests May reflect underlying pathology rather than toxicity Persistent elevation should be confirmed with repeat testing It is important to note that high B12 levels are generally not considered toxic in the same way as fat-soluble vitamins

Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI (2011) Hypoxia leads to Na, K-ATPase downregulation via Ca2+ release-activated Ca2+ channels and AMPK activation

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Behav Brain Res 198:380387 Hodges H (1996) Maze procedures: the radial-arm and water maze compared