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Since only the leak pathway varies with inflammation, this concept provides a solid foundation for the use of the above-described ratio measurements, in that the pore pathways transport the small molecules such as mannitol or 400 (Da) fluorescein isothiocyanate (FITC) 400 whereas larger molecules such as lactulose and FITC 4000 are transported by the variable leak pathway

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Preclinical research has examined AHK-Cu in fibroblast and dermal cell culture models for its effects on collagen and glycosaminoglycan synthesis via TGF- pathway interaction