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The increased IGF1R protein determined a significant increase in proliferation and invasion, further confirming the anti-proliferative and anti-invasive effects of this miRNA

Notably, the majority of valerolactone in urine existed in conjugated forms, suggesting that microbial-derived metabolites, once absorbed, undergo host phase II modification before renal clearance

1 2 J Neuropsychiatry Clin Neurosci

Therefore, considering that PCa is often classified as a cold tumor with a suppressed immune microenvironment, merely promoting apoptosis in PCa cells may not yield satisfactory clinical outcomes

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