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However, in human subjects of the Alzheimers Disease Neuroimaging Initiative (ADNI), the GRN rs5848 AD risk variant, which causes at least 1020% reduction of PGRN protein levels, has no significant effects on florbetapir PET amyloid imaging or cerebrospinal fluid (CSF) A levels, whereas it is associated with increased CSF tau levels [52], suggesting a potential effect of PGRN deficiency on tau pathology, rather than amyloid pathology

Lipid- and water-based vesicles enhance solubility and membrane permeability, facilitating accurate delivery to the target tissues (131)