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5.1.1.2 Omaveloxolone (RTA 408) Omaveloxolone (RTA 408, Skyclarys) or Omav is a semisynthetic oleanane triterpenoid developed by Reeta Pharmaceuticals to target the upregulation of the NRF2 pathway (FARA, 2023b)

[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Zhang Y, Fu Y, Jiang T, Liu B, Sun H, Zhang Y, et al

Chemokine (C-X-C motif) receptor 4 (CXCR4) expression increases during progression of PCa and is associated with metastatic disease and poor survival [50, 51] CXCR4 selectively binds to stromal cell-derived factor 1 (SDF-1)/ CXCL12, also overexpressed in PC metastatic tissue compared to normal tissues [52]

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Aug 2014;90(8):615-621